A remarkable change of opioid receptor selectivity on the attachment of a peptidomimetic kappa address element to the delta antagonist, natrindole: 5'-[N2-alkylamidino)methyl]naltrindole derivatives as a novel class of kappa opioid receptor antagonists

J Med Chem. 1993 Jan 8;36(1):179-80. doi: 10.1021/jm00053a025.
No abstract available

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Guinea Pigs
  • Indoles / chemical synthesis*
  • Indoles / pharmacology*
  • Morphinans / pharmacology*
  • Naltrexone* / analogs & derivatives*
  • Narcotic Antagonists / chemical synthesis*
  • Narcotic Antagonists / pharmacology
  • Receptors, Opioid, delta / antagonists & inhibitors*
  • Receptors, Opioid, delta / metabolism
  • Receptors, Opioid, kappa / antagonists & inhibitors*
  • Receptors, Opioid, kappa / metabolism
  • Structure-Activity Relationship

Substances

  • Indoles
  • Morphinans
  • Narcotic Antagonists
  • Receptors, Opioid, delta
  • Receptors, Opioid, kappa
  • Naltrexone
  • naltrindole